Researcher Database - UYAMA TOORU | Kobe Gakuin University

UYAMA TOORU

Department / Course

Kobe Gakuin University The Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences

Job Professor

Book and thesis
2025/04/03	Papers	Recent Progress in N-Acylethanolamine Research: Biological Functions and Metabolism Regulated by Two Distinct N-Acyltransferases: cPLA2ε and PLAAT Enzymes. International journal of molecular sciences 26 (7)
2025/04	Papers	The PLAAT family as phospholipid-related enzymes. Progress in lipid research 98,pp.101331-101331
2024/11	Papers	PLAAT5 as an N-acyltransferase responsible for the generation of anti-inflammatory N-acylethanolamines in testis Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids,pp.159583-159583
2023/12/20	Papers	PLAAT1 expression triggers fragmentation of mitochondria in an enzyme activity-dependent manner. Journal of biochemistry 175 (1),pp.101-113
2023/07	Papers	PLAAT1 deficiency alleviates high-fat diet-induced hepatic lipid accumulation in mice. FASEB journal : official publication of the Federation of American Societies for Experimental Biology 37 (7),pp.e23032
2023/01/17	Papers	Vasoactive intestinal peptide blockade suppresses tumor growth by regulating macrophage polarization and function in CT26 tumor-bearing mice. Scientific reports 13 (1),pp.927-927
2023	Papers	Assay of NAT Activity. Methods in molecular biology (Clifton, N.J.) 2576,pp.213-224
2022/10/26	Papers	β-1,4-Galactan suppresses lipid synthesis in sebaceous gland cells via TLR4. Journal of biochemistry 173 (2),pp.85-94
2022/08/18	Papers	Formation of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ε in an ex vivo murine model of brain ischemia. Biochimica et biophysica acta. Molecular and cell biology of lipids 1867 (12),pp.159222-159222
2022/07/29	Papers	Defunctionalizing intracellular organelles such as mitochondria and peroxisomes with engineered phospholipase A/acyltransferases. Nature communications 13 (1),pp.4413-4413
2022	Papers	Identification of a N-acyl-dopamine synthase 日本分子生物学会年会プログラム・要旨集(Web)
2021/08	Papers	Involvement of the γ Isoform of cPLA2γ in the Biosynthesis of Bioactive N-Acylethanolamines Molecules 26 (17),pp.5213-5213
2021/06/11	Papers	Roles of Endocannabinoids and Endocannabinoid-like Molecules in Energy Homeostasis and Metabolic Regulation: A Nutritional Perspective. Annual review of nutrition 41,pp.177-202
2021/05/24	Papers	Involvement of acid ceramidase in the degradation of bioactive N-acylethanolamines. Biochimica et biophysica acta. Molecular and cell biology of lipids 1866 (9),pp.158972-158972
2021/05	Papers	Role of Acid Ceramidase in the Hydrolysis of Anti‐inflammatory and Anorexic N ‐Acylethanolamines The FASEB Journal
2021	Papers	Chapter 7: Inhibition of NAPE-PLD Activity by Natural Compounds and Synthetic Drugs, and Its Biological Relevance RSC Drug Discovery Series,pp.301-336
2019/12	Papers	Intracellular Ca2+-dependent formation of N-acyl-phosphatidylethanolamines by human cytosolic phospholipase A2ε. Biochimica et biophysica acta. Molecular and cell biology of lipids 1864 (12),pp.158515-158515
2019/04/01	Papers	The role of intracellular anionic phospholipids in the production of N-acyl-phosphatidylethanolamines by cytosolic phospholipase A2ɛ. Journal of biochemistry 165 (4),pp.343-352
2018/09	Papers	N-アシル-ホスファチジルエタノールアミン特異的ホスホリパーゼD欠損マウスの末梢臓器における関連脂質とその代謝経路の解析日本生化学会大会プログラム・講演要旨集,pp.[2P-066]
2018/05/01	Papers	Phosphatidylserine-stimulated production of N-acyl-phosphatidylethanolamines by Ca2+-dependent N-acyltransferase Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1863 (5),pp.493-502
2018/01	Papers	The biosynthetic pathways of N-acylethanolamines in mammals. eLS,pp.A27711
2018	Papers	Endocannabinoids and related N-acylethanolamines: biological activities and metabolism. Inflammation and regeneration 38,pp.28-28
2017/12	Papers	Mammalian enzymes responsible for the biosynthesis of N-acylethanolamines BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1862 (12),pp.1546-1561
2017/12	Papers	Peripheral tissue levels and molecular species compositions of N-acyl-phosphatidylethanolamine and its metabolites in mice lacking N-acyl-phosphatidylethanolamine-specific phospholipase D JOURNAL OF BIOCHEMISTRY 162 (6),pp.449-458
2017/12	Papers	古くて新しい脂溶性ビタミンの科学脂溶性バイオファクターであるN-アシルエタノールアミンの生合成機構生命科学系学会合同年次大会,pp.[3PW27-2]
2017/09/01	Papers	An involvement of phospholipase A/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism FEBS Letters 591 (18),pp.2745-2760
2016/12	Papers	A quantitative study on splice variants of N-acylethanolamine acid amidase in human prostate cancer cells and other cells. Biochimica et biophysica acta 1861 (12 Pt A),pp.1951-1958
2016/12	Papers	Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7 BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1861 (12),pp.1881-1892
2016/12	Papers	Calcium-dependent generation of N-acylethanolamines and lysophosphatidic acids by glycerophosphodiesterase GDE7. Biochimica et biophysica acta 1861 (12 Pt A),pp.1881-1892
2016/11	Papers	Comparative analyses of isoforms of the calcium-independent phosphatidylethanolamine N-acyltransferase PLAAT-1 in humans and mice JOURNAL OF LIPID RESEARCH 57 (11),pp.2051-2060
2016	Papers	Assay of NAT activity Methods in Molecular Biology 1412,pp.113-122
2015/12	Papers	PLAAT-3はPex19pを介してペルオキシソーム含量を制御する日本生化学会大会・日本分子生物学会年会合同大会講演要旨集,pp.[1T特p-09(1P0312)]
2015/10	Papers	[Peroxisomal regulation by phospholipase A/acyltransferase-3]. Seikagaku. The Journal of Japanese Biochemical Society,pp.633-635
2015/07	Papers	Interaction of Phospholipase A/Acyltransferase-3 with Pex19p A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES JOURNAL OF BIOLOGICAL CHEMISTRY 290 (28),pp.17520-17534
2015/05	Papers	Eicosapentaenoic acid upregulates VEGF-A through both GPR120 and PPAR gamma mediated pathways in 3T3-L1 adipocytes MOLECULAR AND CELLULAR ENDOCRINOLOGY 406 (C),pp.10-18
2015/05	Papers	Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1851 (5),pp.537-548
2015/05	Papers	Glycerophosphodiesterase GDE4 as a novel lysophospholipase D: a possible involvement in bioactive N-acylethanolamine biosynthesis. Biochimica et biophysica acta 1851 (5),pp.537-548-548
2015/05	Papers	PLA/AT-3によるペルオキシソーム形成の制御にはPex19pが関与する脂質生化学研究,pp.122-125
2015	Books	Metabolic Enzymes for Endocannabinoids and Endocannabinoid-Like Mediators (Co-authored)
2014/09/19	Papers	Metabolic Enzymes for Endocannabinoids and Endocannabinoid-Like Mediators The Endocannabinoidome: The World of Endocannabinoids and Related Mediators,pp.111-135
2014/08	Papers	New players in the fatty acyl ethanolamide metabolism PHARMACOLOGICAL RESEARCH 86,pp.1-10
2013/12	Papers	Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1831 (12),pp.1690-1701
2013/12	Papers	Involvement of phospholipase A/acyltransferase-1 in N-acylphosphatidylethanolamine generation. Biochimica et biophysica acta 1831 (12),pp.1690-1701-1701
2013/05	Papers	Metabolism of endocannabinoids and related N-acylethanolamines: Canonical and alternative pathways FEBS JOURNAL 280 (9),pp.1874-1894
2013/04	Papers	LRATに相同性を示す新規リン脂質代謝酵素によるペルオキシソームの機能調節ビタミン,pp.253-253
2013/02	Papers	Biosynthetic Pathways of Bioactive N-Acylethanolamines in Brain CNS & NEUROLOGICAL DISORDERS-DRUG TARGETS 12 (1),pp.7-16
2013	Papers	Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways VITAMINS,pp.267-270
2012/12	Papers	Phospholipase A/Acyltransferaseファミリーによる細胞内ペルオキシソーム含量の制御日本生化学会大会プログラム・講演要旨集,pp.2P-129
2012/09	Papers	Generation of N-Acylphosphatidylethanolamine by Members of the Phospholipase A/Acyltransferase (PLA/AT) Family JOURNAL OF BIOLOGICAL CHEMISTRY 287 (38),pp.31905-31919
2012/05	Papers	Endogenous Molecules Stimulating N-Acylethanolamine-Hydrolyzing Acid Amidase (NAAA) ACS CHEMICAL NEUROSCIENCE 3 (5),pp.379-385
2012/01	Papers	Regulation of Peroxisomal Lipid Metabolism by Catalytic Activity of Tumor Suppressor H-rev107 JOURNAL OF BIOLOGICAL CHEMISTRY 287 (4),pp.2706-2718
2011/11	Papers	Enzymological analysis of the tumor suppressor A-C1 reveals a novel group of phospholipid-metabolizing enzymes JOURNAL OF LIPID RESEARCH 52 (11),pp.1927-1935
2011/11	Papers	Oleoylethanolamide as an appetite-suppressing mediator VITAMINS,pp.604-607
2011/10	Papers	Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1811 (10),pp.565-577
2011/10	Papers	Enzymatic formation of N-acylethanolamines from N-acylethanolamine plasmalogen through N-acylphosphatidylethanolamine-hydrolyzing phospholipase D-dependent and -independent pathways. Biochimica et biophysica acta 1811 (10),pp.565-577
2011/01	Papers	Biosynthesis and degradation of the endocannabinoid 2-arachidonoylglycerol BIOFACTORS 37 (1),pp.1-7
2011	Papers	Metabolism of N-acylphosphatidylethanolamine, a phospholipid molecule with three acyl chains, in animal tissues Seikagaku,pp.485-494
2010/12	Papers	Enzymological studies on the biosynthesis of N-acylethanolamines. Biochimica et biophysica acta 1801 (12),pp.1274-1285
2010/10	Papers	N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA) PROGRESS IN LIPID RESEARCH 49 (4),pp.299-315
2010/03	Papers	Heparanase-enhanced shedding of syndecan-1 by myeloma cells promotes endothelial invasion and angiogenesis BLOOD 115 (12),pp.2449-2457
2009/12	Papers	Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1791 (12),pp.1114-1124
2009/12	Papers	Characterization of the human tumor suppressors TIG3 and HRASLS2 as phospholipid-metabolizing enzymes. Biochimica et biophysica acta 1791 (12),pp.1114-1124
2009/04	Papers	The tumor suppressor gene H-Rev107 functions as a novel Ca(2+)-independent cytosolic phospholipase A(1/2) of the thiol hydrolase type JOURNAL OF LIPID RESEARCH 50 (4),pp.685-693
2009/01	Papers	cDNA cloning and characterization of human and mouse Ca(2+)-independent phosphatidylethanolamine N-acyltransferases. Biochimica et biophysica acta 1791 (1),pp.32-38
2009/01	Papers	cDNA cloning and characterization of human and mouse Ca2+-independent phosphatidylethanolamine N-acyltransferases BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1791 (1),pp.32-38
2008/11	Papers	Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1781 (11-12),pp.710-717
2008/11	Papers	Amino acid residues crucial in pH regulation and proteolytic activation of N-acylethanolamine-hydrolyzing acid amidase. Biochimica et biophysica acta 1781 (11-12),pp.710-717
2008/11	Papers	Expression and Secretion of N-acylethanolamine-hydrolysing Acid Amidase in Human Prostate Cancer Cells JOURNAL OF BIOCHEMISTRY 144 (5),pp.685-690
2007/05	Papers	Involvement of chondroitin sulfate synthase-3 (chondroitin synthase-2) in chondroitin polymerization through its interaction with chondroitin synthase-1 or chondroitin-polymerizing factor BIOCHEMICAL JOURNAL 403 (3),pp.545-552
2007/01/01	Papers	Biosynthesis of Glycosaminoglycans and Proteoglycans Comprehensive Glycoscience: From Chemistry to Systems Biology 3-4,pp.79-104
2006/12	Papers	Chondroitin 4-O-sulfotransferase-1 regulates E disaccharide expression of chondroitin sulfate required for herpes simplex virus infectivity JOURNAL OF BIOLOGICAL CHEMISTRY 281 (50),pp.38668-38674
2005/09	Papers	Chondroitin sulfate characterized by the E-disaccharide unit is a potent inhibitor of herpes simplex virus infectivity and provides the virus binding sites on gro2C cells JOURNAL OF BIOLOGICAL CHEMISTRY 280 (37),pp.32193-32199
2005/01/01	Papers	Biosynthetic pathways for differential expression of functional chondroitin sulfate and heparan sulfate Handbook of Carbohydrate Engineering,pp.289-324
2004/02	Papers	[Chondroitin sugars in embryonic cell division of the nematode C. elegans]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,pp.141-147
2003/10	Papers	Recent advances in the structural biology of chondroitin sulfate and dermatan sulfate CURRENT OPINION IN STRUCTURAL BIOLOGY 13 (5),pp.612-620
2003/06	Papers	Molecular cloning of a chondroitin polymerizing factor that cooperates with chondroitin synthase for chondroitin polymerization JOURNAL OF BIOLOGICAL CHEMISTRY 278 (26),pp.23666-23671
2003/06	Papers	[Proteoglycan core glycosyltransferases]. Tanpakushitsu kakusan koso. Protein, nucleic acid, enzyme,pp.1019-1026
2003/05	Papers	Chondroitin proteoglycans are involved in cell division of Caenorhabditis elegans NATURE 423 (6938),pp.443-448
2003/01	Papers	Molecular cloning and expression of a second chondroitin N-acetylgalactosaminyltransferase involved in the initiation and elongation of chondroitin/dermatan sulfate JOURNAL OF BIOLOGICAL CHEMISTRY 278 (5),pp.3072-3078
2002/08	Papers	ポストゲノム研究のミッシング・リンク-糖鎖シグナルによる生体機能調節線虫グリコーム関連遺伝子のRNAiによる解析-中間報告生化学,pp.648-648
2002/08	Papers	細胞分化と分裂を制御する糖鎖の解析生化学,pp.803-803
2002/03	Papers	Molecular cloning and expression of human chondroitin N-acetylgalactosaminyltransferase - The key enzyme for chain initiation and elongation of chondroitin/dermatan sulfate on the protein linkage region tetrasaccharide shared by heparin/heparan sulfate JOURNAL OF BIOLOGICAL CHEMISTRY 277 (11),pp.8841-8846
2001/10	Papers	Molecular cloning and expression of a human chondroitin synthase JOURNAL OF BIOLOGICAL CHEMISTRY 276 (42),pp.38721-38726