Researcher Database - NAKAGAWA KIMIE | Kobe Gakuin University

NAKAGAWA KIMIE

Department / Course

Kobe Gakuin University The Faculty of Pharmaceutical Sciences Department of Pharmaceutical Sciences

Job Professor

Book and thesis
2022/09	Papers	Characterization of Astrocytes in the Minocycline-Administered Mouse Photothrombotic Ischemic Stroke Model. Neurochemical research 47 (9),pp.2839-2855
2022	Papers	Vitamin D Status in Japanese Young Women in 2016-2017 and 2020: Seasonal Variation and the Effect of Lifestyle Including Changes Caused by the COVID-19 Pandemic. Journal of nutritional science and vitaminology 68 (3),pp.172-180
2021/05	Papers	Concise Preparation and Biological Evaluations of 9-cis-Retinoic Acid Analogues Having an Aromatic Ring HETEROCYCLES,pp.267-267
2021/04/15	Papers	Elucidation of metabolic pathways of 25-hydroxyvitamin D3 mediated by Cyp24a1 and Cyp3a using Cyp24a1 knockout rats generated by CRISPR/Cas9 system. The Journal of biological chemistry,pp.100668-100668
2020/11	Papers	Induced mRNA expression of matrix metalloproteinases Mmp-3, Mmp-12, and Mmp-13 in the infarct cerebral cortex of photothrombosis model mice NEUROSCIENCE LETTERS 739,pp.135406-135406
2020/10	Papers	Generation of Novel Genetically Modified Rats to Reveal the Molecular Mechanisms of Vitamin D Actions,pp.517-520
2020/04	Papers	Induced Prostanoid Synthesis Regulates the Balance between Th1-and Th2-Producing Inflammatory Cytokines in the Thymus of Diet-Restricted Mice BIOLOGICAL & PHARMACEUTICAL BULLETIN 43 (4),pp.649-662
2020/03	Papers	Generation of novel genetically modified rats to reveal the molecular mechanisms of vitamin D actions SCIENTIFIC REPORTS 10 (1),pp.5677-5677
2020	Papers	Biased polarization of immature thymic T cells during dexamethasoneinduced thymic involution Journal of Toxicological Sciences 45 (Supplement),pp.S79-S79
2020	Papers	Diseases due to the deficiency in vitamin K conversion system and its prevention 日本薬学会年会要旨集(CD-ROM),pp.S47-1
2020	Papers	Vitamin K metabolism and biotransformation of vitamin K into menaquinone-4 ビタミン,pp.178-183
2019/06	Papers	フタル酸エステルによる妊娠子宮での細胞増殖阻害(Defect in cell proliferation caused by phthalate in the pregnant uterus) The Journal of Toxicological Sciences 44 (Suppl.),pp.S339-S339
2019/04	Papers	UBIAD1 Plays an Essential Role in the Survival of Pancreatic Acinar Cells INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES 20 (8)
2019/01	Papers	Generation of 1,25-dihydroxyvitamin D-3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D-3 rescued their rachitic phenotypes JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 185,pp.71-79
2019	Papers	Mechanism of the conversion of vitamin K into menaquinone-4 and its physiological significance ビタミン
2019	Papers	ビタミンKに蛍光基NBDを導入した新規蛍光プローブによるSXRの細胞内局在変化ビタミン,pp.219-219
2019	Papers	未知のビタミンK結合タンパク質の同定を目指した新規蛍光プローブによる核内受容体SXRの細胞内局在変化日本薬学会年会要旨集(CD-ROM),pp.126-126
2019	Papers	生体内におけるCYP24A1およびCYP3A依存性ビタミンD代謝解析ビタミン,pp.184-184
2018/10	Papers	Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice PLOS ONE 13 (10),pp.e0199856
2018/08	Papers	Synthesis of novel fluorescent probes to elucidate vitamin K binding protein ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256
2018/07/19	Papers	Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells Symposium on the Chemistry of Natural Products, symposium papers
2018/03	Papers	CYP24A1遺伝子欠損ラットを用いた25-ヒドロキシビタミンD3代謝様式の解明日本薬学会年会要旨集,pp.142-142
2018/03	Papers	ゲノム編集法により作成したCYP27B1遺伝子欠損およびVDR遺伝子改変ラットを用いたビタミンD作用メカニズムの解明日本薬学会年会要旨集,pp.139-139
2018/02	Papers	Expression of tissue inhibitor of metalloproteinases and matrix metalloproteinases in the ischemic brain of photothrombosis model mice NEUROREPORT 29 (3),pp.174-180
2018	Papers	CYP24A1遺伝子改変ラットを用いた25‐ヒドロキシビタミンD₃の代謝解明ビタミン,pp.238
2018	Papers	CYP24A1遺伝子欠損ラットを用いた25‐ヒドロキシビタミンD3代謝様式の解明日本生化学会大会(Web),pp.ROMBUNNO.3P‐140 (WEB ONLY)-140]
2018	Papers	CYP24A1遺伝子欠損ラットを用いた25‐ヒドロキシビタミンD3代謝様式の解明日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.26PA‐am229-142
2018	Papers	ゲノム編集法で作製したVDR遺伝子改変ラットの表現型解析による新規ビタミンD作用メカニズムの解明ビタミン,pp.238
2018	Papers	ゲノム編集法で作製したビタミンD関連遺伝子改変ラットを用いた新規ビタミンD作用機序の解明ビタミン,pp.237
2018	Papers	ゲノム編集法で作製した変異型VDR導入ラットにおける25(OH)ビタミンD₃およびビタミンD誘導体の活性評価ビタミン,pp.237
2018	Papers	ゲノム編集法により作成したCYP27B1遺伝子欠損およびVDR遺伝子改変ラットを用いたビタミンD作用メカニズムの解明日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.26PA‐am210-139
2018	Papers	Synthesis of Novel Vitamin K Fluorescent Probes for Labeling of Binding Proteins 天然有機化合物討論会講演要旨集(Web)
2018	Papers	ビタミンK結合タンパク質を蛍光標識する新規プローブの合成メディシナルケミストリーシンポジウム講演要旨集,pp.163
2018	Papers	再生医療を志向した神経分化誘導物質の創製芝浦工業大学特別教育・研究報告集(CD-ROM),pp.312‐315
2018	Papers	新規ビタミンK蛍光プローブの合成およびビタミンK結合タンパク質の解析ビタミン,pp.229-229
2017/07	Papers	Determination of Menadione by Liquid Chromatography-Tandem Mass Spectrometry Using Pseudo Multiple Reaction Monitoring ANALYTICAL SCIENCES 33 (7),pp.863-867
2017/01	Papers	Nongenomic effects of 1 alpha,25-dihydroxyvitamin D-3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 483 (1),pp.359-365
2017	Papers	CYP24A1遺伝子欠損ラットを用いた25-ヒドロキシビタミンD3代謝様式の解明生命科学系学会合同年次大会,pp.[3P-0213]
2017	Papers	Cyp27b1およびVdr欠損マウスの比較から1α,25D₃は軟骨形成においてnongenomic作用を示す日本フードファクター学会学術集会講演要旨集,pp.107
2017	Papers	CYP27B1遺伝子欠損ラットにおける25(OH)ビタミンD₃の代謝と生理作用ビタミン,pp.267
2017	Papers	LC/MS/MSを利用した血中ビタミンD3代謝物の一斉分析法の確立生命科学系学会合同年次大会,pp.[3P-0212]
2017	Papers	ゲノム編集法で作出したCYP27B1 KOおよび変異型VDR導入ラットの比較による25-ヒドロキシビタミンD3の作用メカニズムの解明生命科学系学会合同年次大会,pp.[3P-0211]
2017	Papers	ゲノム編集法で作出したI型くる病モデルCYP27B1遺伝子欠損ラットへの25-ヒドロキシビタミンD3投与の効果生命科学系学会合同年次大会,pp.[3P-0210]
2017	Papers	ゲノム編集法により作製したCYP27B1遺伝子欠損およびビタミンD受容体遺伝子改変ラットを用いたビタミンD作用メカニズムの解明日本生化学会大会(Web),pp.ROMBUNNO.3P‐0209 (WEB ONLY)-0209]
2017	Papers	ゲノム編集法を用いたVDR,CYP27B1,CYP24A1遺伝子改変ラットの創製ビタミン,pp.267-267
2017	Papers	ビタミンK₁水素付加物(2’,3’‐PKH₂)の生体内代謝機構ビタミン,pp.291
2017	Papers	新規ビタミンK誘導体の合成と生理活性の検討ビタミン,pp.142‐143
2017	Papers	水素付加したビタミンK₁の生体内代謝機構の解析日本生化学会大会(Web),pp.[3P-1292]
2017	Papers	水素添加したビタミンK1(2’,3’‐PKH2)の代謝機構日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.27PA‐pm026
2017	Papers	脳神経特異的ビタミンK2合成酵素UBIAD1欠損マウスの脳機能解析ビタミン,pp.264-264
2017	Papers	脳神経特異的ビタミンK2合成酵素UBIAD1欠損マウスの表現型解析日本薬学会年会要旨集,pp.226-226
2016	Papers	ニューロンへの分化を高選択的に誘導する新規メナキノン誘導体の合成メディシナルケミストリーシンポジウム講演要旨集,pp.195
2016	Papers	ビタミンK₂変換酵素UBIAD1タンパク質の機能解析衛生薬学・環境トキシコロジー講演要旨集,pp.262
2016	Papers	ビタミンK₂変換酵素UBIAD1タンパク質の機能解析日本生化学会大会(Web),pp.ROMBUNNO.2P‐153 (WEB ONLY)
2016	Papers	ビタミンKの側鎖末端を修飾した誘導体の合成と核内受容体SXRに対する転写活性の検討ビタミン,pp.198
2016	Papers	ビタミンK合成機構解明を目指した側鎖切断酵素の探索日本フードファクター学会学術集会講演要旨集,pp.34
2016	Papers	ビタミンK合成酵素UBIAD1タンパク質の機能解析ビタミン,pp.199
2016	Papers	ビタミンK合成酵素のタンパク質機能解析日本薬学会関東支部大会講演要旨集,pp.ROMBUNNO.P‐53
2016	Papers	ビタミンK変換酵素UBIAD1タンパク質の機能解析日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.29AB‐AM284
2016	Papers	二本の側鎖とその末端にフェニル基を導入した新規ビタミンK誘導体の合成ビタミン,pp.197
2016	Papers	側鎖末端にヘテロ原子を導入した新規ビタミンK誘導体の合成と神経分化誘導作用の検討日本薬学会関東支部大会講演要旨集,pp.ROMBUNNO.C‐19
2016	Papers	側鎖末端を修飾したビタミンK誘導体の合成と標的タンパク質との相互作用の検討日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.28AB‐AM269
2016	Papers	Synthesis of novel vitamin K derivatives with introduction of a hetero atom in the side chain and evaluation of the neuronal differentiation activity Symposium on the Chemistry of Natural Products, symposium papers,pp.Poster53
2015/09	Papers	Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells JOURNAL OF MEDICINAL CHEMISTRY 58 (17),pp.7088-7092
2015/05	Papers	YY1 positively regulates human UBIAD1 expression BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 460 (2),pp.238-244
2015/04	Papers	Functional Characterization of the Vitamin K-2 Biosynthetic Enzyme UBIAD1 PLOS ONE 10 (4),pp.e0125737
2015	Papers	PARP-1はビタミンK変換酵素UBIAD1遺伝子の転写を促進する日本薬学会年会要旨集,pp.216-216
2015	Papers	PKCシグナル伝達経路の活性化に介してPARP‐1はビタミンK₂合成酵素UBIAD1遺伝子を正に制御する衛生薬学・環境トキシコロジー講演要旨集,pp.225
2015	Papers	PKCシグナル伝達経路の活性化を介してPARP‐1はビタミンK2変換酵素UBIAD1遺伝子を正に制御する日本生化学会大会(Web),pp.1P0674 (WEB ONLY)
2015	Papers	PKC活性化剤PMAはビタミンK変換酵素UBIAD1遺伝子を正に制御するビタミン,pp.247-247
2015	Papers	ニューロンヘの分化を誘導する新規ビタミンK誘導体の合成と作用メカニズムの解析日本薬学会関東支部大会講演要旨集,pp.102
2015	Papers	ニューロンへの分化を誘導する新規ビタミンK誘導体の合成と簡便な活性評価法の検討日本薬学会年会要旨集,pp.246-246
2015	Papers	ニューロンへの分化を誘導する新規ビタミンK誘導体の探索と作用メカニズムの解析天然有機化合物討論会講演要旨集(Web),pp.429‐434(J‐STAGE)
2015	Papers	ビタミンK2合成酵素Ubiad1遺伝子欠損マウスの表現型解析ビタミン,pp.257-257
2015	Papers	ビタミンK2合成酵素Ubiad1遺伝子欠損マウスは胎生致死となる日本薬学会年会要旨集,pp.215-215
2015	Papers	ビタミンK誘導体の分化誘導作用を評価するための簡便なスクリーニング法の検討ビタミン,pp.234-234
2015	Papers	標的タンパク質への作用増強を目指した新規ビタミンK誘導体の合成と生物活性評価メディシナルケミストリーシンポジウム講演要旨集,pp.141
2014/08	Papers	Vitamin K-2 Biosynthetic Enzyme, UBIAD1 Is Essential for Embryonic Development of Mice PLOS ONE 9 (8),pp.e104078
2014/02	Papers	Effect of Dietary Calcium and Sodium on Blood Pressure and Its Related Gene Expression in Cyp27b1 Knockout Mice. JOURNAL OF BONE AND MINERAL RESEARCH 29,pp.S254-S255
2014/02	Papers	Liver-Specific gamma-Glutamyl Carboxylase-Deficient Mice Display Bleeding Diathesis and Short Life Span PLOS ONE 9 (2),pp.e88643
2014/02	Papers	Menaquinone-4 (Vitamin K-2) in Bone Originates from Menadione (Vitamin K-3) Released from Oral Phylloquinone (Vitamin K-1) During Intestinal Absorption. JOURNAL OF BONE AND MINERAL RESEARCH 29,pp.S250-S250
2014	Papers	CYP27B1ノックアウトマウス腎臓近位尿細管初代培養細胞における25‐ヒドロキシビタミンD3の生理作用日本生化学会大会(Web),pp.3P-149 (WEB ONLY)
2014	Papers	ニューロンへの分化を誘導する新規ビタミンK誘導体の創製ビタミン,pp.106-107
2014	Papers	Synthetic Small Molecules Derived from Natural Vitamin K Homologues that Induce Selective Neuronal Differentiation of Neuronal Progenitor Cells Symposium on the Chemistry of Natural Products, symposium papers,pp.Poster6
2014	Papers	ビタミンK側鎖切断組織の同定と側鎖切断体の探索ビタミン,pp.218-218
2014	Papers	ビタミンK側鎖切断酵素の探索日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.30T-PM05-85
2014	Papers	ビタミンK変換酵素の発現制御機構に関する研究衛生薬学・環境トキシコロジー講演要旨集,pp.193
2014	Papers	ヒトおよびラットにおけるビタミンK側鎖切断酵素の探索日本生化学会大会(Web),pp.4T15A-12(4P-368) (WEB ONLY)
2014	Papers	円二色性分散計を用いた核内受容体SXRの脂溶性ビタミン認識特性の解析ビタミン,pp.220-220
2014	Papers	核内受容体SXRの脂溶性リガンド認識特性の解析日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.30T-AM01-83
2013/12	Papers	Biological Significance and Metabolic Activation of Vitamin K YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,pp.1337-1341
2013/11	Papers	Menadione (Vitamin K-3) Is a Catabolic Product of Oral Phylloquinone (Vitamin K-1) in the Intestine and a Circulating Precursor of Tissue Menaquinone-4 (Vitamin K-2) in Rats JOURNAL OF BIOLOGICAL CHEMISTRY 288 (46),pp.33071-33080
2013/04	Papers	GENE STRUCTURE ANALYSIS OF A NOVEL HUMAN MENAQUINONE-4 BIOSYNTHETIC ENZYME UBIAD1 THAT REGULATES OSTEOBLAST FUNCTION OSTEOPOROSIS INTERNATIONAL 24,pp.S242-S242
2013/02	Papers	Accumulation of Menaqunone-4 in the Bones of Mice Orally Given K Vitamers and Its Biological Activity in Osteoblasts. JOURNAL OF BONE AND MINERAL RESEARCH 28
2013	Papers	CYP27B1ノックアウトマウスの腎臓近位尿細管初代培養細胞におけるビタミンD代謝解析ビタミン,pp.218-218
2013	Papers	CYP27B1ノックアウトマウス腎臓近位尿細管初代培養細胞における25‐ヒドロキシビタミンD3の生理作用日本生化学会大会(Web),pp.WEB ONLY 3P-170-170
2013	Papers	Menaquinone‐4生合成酵素UBIAD1の発現制御機構に関する研究日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.30S-PM01S-213
2013	Papers	Menaquinone‐4生合成酵素UBIAD1遺伝子の発現制御因子の探索ビタミン,pp.227-227
2013	Papers	UBIAD1-mediated vitamin K_2 synthesis is required for vascular homeostasis maintenance VITAMINS,pp.691-695
2013	Papers	ニューロンへの分化を誘導する新規ビタミンK誘導体の開発ビタミン,pp.228-228
2013	Papers	ニューロンへの分化誘導作用を有する新規ビタミンK誘導体の構造活性相関の検討メディシナルケミストリーシンポジウム講演要旨集,pp.125
2013	Papers	ビタミンK2生合成酵素UBIAD1の神経細胞分化調節作用ビタミン,pp.226-226
2013	Papers	ラットにおけるビタミンKの吸収ならびに代謝機構についてビタミン,pp.654-655
2013	Papers	脳神経幹細胞からニューロンへの分化を誘導する新規ビタミンK誘導体の合成日本薬学会年会要旨集(CD-ROM),pp.ROMBUNNO.29PMA-130-203
2012/08	Papers	Structure-Activity Relationship of Novel Vitamin K Analogues as Steroid and Xenobiotic Receptor (SXR) Agonists YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN,pp.881-886
2012/04	Papers	New Development of Vitamin K Research: Identification of Human Menaquinone-4 Biosynthetic Enzyme JOURNAL OF FOOD AND DRUG ANALYSIS 20,pp.371-375
2012/02	Papers	Structure-Activity Relationship of Novel Menaquinone-4 Analogues: Modification of the Side Chain Affects their Biological Activities JOURNAL OF MEDICINAL CHEMISTRY 55 (4),pp.1553-1558
2012	Papers	ニューロンへの分化を誘導する新規ビタミンK誘導体の創製メディシナルケミストリーシンポジウム講演要旨集,pp.80
2012	Papers	ニューロンへの分化を誘導する新規ビタミンK誘導体の創製日本薬学会年会要旨集,pp.267-267
2012	Papers	ニューロンヘの分化を誘導する新規ビタミンK誘導体の合成と構造活性相関の検討ビタミン,pp.277-277
2012	Papers	ビタミンK₂(メナキノン4)生合成酵素UBIAD1の酵素化学的性質の解析日本農芸化学会大会講演要旨集(Web),pp.WEB ONLY 2C09P17
2012	Papers	ビタミンK2(メナキノン-4)生合成酵素の構造と機能解析 Osteoporosis Japan,pp.25-30
2012	Papers	Identification of vitamin K_2 (menaquinone-4) biosynthetic enzyme VITAMINS,pp.441-444
2012	Papers	マウス胎仔大脳由来神経幹細胞に対するビタミンKの分化誘導作用日本薬学会年会要旨集,pp.87-87
2012	Papers	Synthesis of novel vitamin K analogues with modification at ω-terminal position and evaluation of their transcriptional activity via steroid and xenobiotic receptor (SXR) ビタミン,pp.493-498
2012	Papers	酵素は何をしているのか?新世紀の科学が解き明かす分子メカニズム新規ヒト膜結合型ビタミンK2合成酵素UBIAD1 創薬の新たな標的となりうるか日本薬学会年会要旨集,pp.202-202
2011/07	Papers	Synthesis of New Vitamin K Analogues as Steroid and Xenobiotic Receptor (SXR) Agonists: Insights into the Biological Role of the Side Chain Part of Vitamin K JOURNAL OF MEDICINAL CHEMISTRY 54 (13),pp.4918-4922
2011/06	Papers	Inhibitory Effect of 1 alpha-Hydroxyvitamin D-3 on N-nitrosobis (2-oxopropyl)Amine-induced Cholangiocarcinogenesis in Syrian Hamsters ACTA MEDICA OKAYAMA 65 (3),pp.193-197
2011/06	Papers	Synthesis of Novel Vitamin K-2 Analogues with Modification at the omega-Terminal Position and Their Biological Evaluation as Potent Steroid and Xenobiotic Receptor (SXR) Agonists JOURNAL OF MEDICINAL CHEMISTRY 54 (12),pp.4269-4273
2011/05	Papers	Replacement of the hydrophobic part of 9-cis-retinoic acid with cyclic terpenoid moiety results in RXR-selective agonistic activity BIOORGANIC & MEDICINAL CHEMISTRY 19 (9),pp.2939-2949
2011	Papers	ビタミンDおよびビタミンKの脳神経細胞分化に及ぼす作用日本薬学会年会要旨集,pp.102-102
2011	Papers	The development of therapeutic agents based on vitamin D and vitamin K for the treatment of cancers and osteoporosis. ビタミン
2011	Papers	ビタミンD、KとアンチエイジングビタミンDとビタミンKの基礎研究領域における新たな展開日本抗加齢医学会総会プログラム・抄録集,pp.140-140
2011	Papers	ビタミンK2(Menaquinone-4)生合成酵素UBIAD1の同定日本骨代謝学会学術集会プログラム抄録集,pp.181-181
2011	Papers	ビタミンK2(Menaquinone-4)生合成酵素の発見ビタミン,pp.258-258
2011	Papers	ビタミンK2(メナキノン‐4)生合成酵素の構造と機能解析 Osteoporosis Jpn,pp.301-301
2011	Papers	ビタミンK2生合成酵素の同定日本生化学会大会プログラム・講演要旨集,pp.4T10a-18
2011	Papers	ビタミンKの代謝的活性化と骨作用の分子機構骨形成を助けるビタミンK2変換酵素の発見化学と生物,pp.372-374
2011	Papers	Evaluation of the Biological Action Mechanism of Vitamin K Homologues with Chemical Techniques ビタミン,pp.271-279
2011	Papers	新世紀の創薬を支える現代化学とマルチスケールシミュレーション脂溶性ビタミンの活性化とホルモン応答の多様性日本薬学会年会要旨集,pp.254-254
2011	Papers	脳神経細胞の分化に対するビタミンDの作用ビタミン,pp.255-255
2010/12	Papers	New Developments in Research on Vitamin K Biosynthesis JOURNAL OF HEALTH SCIENCE 56 (6),pp.623-631
2010/12	Papers	Role for vitamin D receptor in the neuronal control of the hematopoietic stem cell niche BLOOD 116 (25),pp.5528-5535
2010/11	Papers	Identification of UBIAD1 as a novel human menaquinone-4 biosynthetic enzyme NATURE 468 (7320),pp.117-+
2010/08	Papers	Efficient synthesis and biological evaluation of demethyl geranylgeranoic acid derivatives BIOORGANIC & MEDICINAL CHEMISTRY 18 (16),pp.5795-5806
2010/05	Papers	Structure-activity relationships in the conversion of vitamin K analogues into menaquinone-4. Substrates essential to the synthesis of menaquinone-4 in cultured human cell lines BIOORGANIC & MEDICINAL CHEMISTRY 18 (9),pp.3116-3124
2010/03	Papers	Synthesis and Biological Evaluation of 9Z-Retinoic Acid Analogs Having 2-Substituted Benzo[b]furan CHEMICAL & PHARMACEUTICAL BULLETIN 58 (3),pp.418-422
2010/02	Papers	Depressed expression of Klotho and FGF receptor 1 in hyperplastic parathyroid glands from uremic patients KIDNEY INTERNATIONAL 77 (3),pp.232-238
2010	Papers	Evaluation of the Biological Action Mechanism of Vitamin K Homologues with Chemical Techniques Symposium on the Chemistry of Natural Products, symposium papers,pp.313-318
2009/12	Papers	[In vivo metabolism of vitamin K: in relation to the conversion of vitamin K1 to MK-4]. Clinical calcium,pp.1779-1787
2008/09	Papers	Conversion of Vitamin K Analogues to Menaquinone-4 in Osteoblastic Cells. JOURNAL OF BONE AND MINERAL RESEARCH 23,pp.S389-S389
2008/09	Papers	Preparation and biological evaluation of 5-substituted retinoic acids BIOORGANIC & MEDICINAL CHEMISTRY 16 (18),pp.8471-8481
2008/09	Papers	Synthesis and development of biologically active fluorescent-labeled vitamin K analogues and monitoring of their subcellular distribution TETRAHEDRON 64 (37),pp.8789-8796
2008/04	Papers	Conversion of phylloquinone (vitamin K-1) into menaquinone-4 (vitamin K-2) in mice JOURNAL OF BIOLOGICAL CHEMISTRY 283 (17),pp.11270-11279
2008/03	Papers	Design and synthesis of biologically active analogues of vitamin K-2: Evaluation of their biological activities with cultured human cell lines BIOORGANIC & MEDICINAL CHEMISTRY 16 (6),pp.3108-3117
2008	Papers	脳および骨はMenaquinone‐4を生合成する日本骨代謝学会学術集会プログラム抄録集,pp.188-188
2008	Papers	重水素標識体を用いたメナキノン‐4の生合成経路の解析日本薬学会年会要旨集,pp.185
2008	Papers	重水素標識化ゲラニルゲラニル二リン酸を用いたメナキノン‐4の生合成反応機構の解析ビタミン,pp.264-264
2008	Papers	骨におけるMenaquinone‐4の生合成ビタミン,pp.263-263
2007/09	Papers	Biosynthesis of menaquinone-4 (Vitamin k2) from phylloquinone (Vitamin k1) and menadione (Vitamin k3) in bone JOURNAL OF BONE AND MINERAL RESEARCH 22,pp.S264-S264
2007/09	Papers	Preparation and biological activities of heteroarotinoids LETTERS IN DRUG DESIGN & DISCOVERY 4 (6),pp.442-445
2007/09	Papers	Synthesis and biological evaluation of vitamin k(2) metabolites JOURNAL OF BONE AND MINERAL RESEARCH 22,pp.S295-S295
2007/09	Papers	Synthesis of gamma-hydroxybutenolides applying crossed aldol condensation in the presence of a bulky lewis acid and their anti-tumor activity CHEMICAL & PHARMACEUTICAL BULLETIN 55 (9),pp.1365-1370
2007/06	Papers	Catalytic asymmetric synthesis and anticancer effects of the novel non-calcemic analog of vitamin D, 2 alpha-fluoro-19-nor-22-oxa-1 alpha, 25-dihydroxyvitamin D-3 in metastatic lung carcinoma JOURNAL OF FLUORINE CHEMISTRY 128 (6),pp.654-667
2007/03	Papers	Efficient sythesis and biological evaluation of omega-oxygenated analogues of vitamin K-2: Study of modification and structure-activity relationship of vitamin K-2 metabolites BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 (6),pp.1622-1625
2007/02	Papers	A functional single nucleotide polymorphism in the vitamin-K-dependent gamma-glutamyl carboxylase gene (Arg325Gln) is associated with bone mineral density in elderly Japanese women BONE 40 (2),pp.451-456
2007	Papers	ヒト由来各種株化細胞におけるメナキノン‐4生合成に関する研究ビタミン,pp.190-190
2007	Papers	代謝物を基にした生理活性を有する新規ビタミンK誘導体の開発 Osteoporosis Jpn,pp.161-161
2007	Papers	培養細胞におけるメナキノン‐4の生合成に関する研究日本薬学会年会要旨集,pp.25
2007	Papers	生理活性を有する新規ビタミンK誘導体の開発メディシナルケミストリーシンポジウム講演要旨集,pp.166-167
2006/11	Papers	Biological activities of 2 alpha-substituted analogues of 1 alpha,25-dihydroxyvitamin D-3 in transcriptional regulation and human promyelocytic leukemia (HL-60) cell proliferation and differentiation BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 (11),pp.2246-2250
2006/10	Papers	Comparative uptake, metabolism, and utilization of menaquinone-4 and phylloquinone in human cultured cell lines BIOORGANIC & MEDICINAL CHEMISTRY 14 (19),pp.6601-6607
2006/09	Papers	Antitumoral activity of 13-demethyl or 13-substituted analogues of all-trans retinoic acid and 9-cis retinoic acid in the human myeloid leukemia cell line HL-60 BIOLOGICAL & PHARMACEUTICAL BULLETIN 29 (9),pp.1803-1809
2006/09	Papers	Development of a biologically active fluorescent-labeled vitamin K and monitoring of the subcellular distribution in cells. JOURNAL OF BONE AND MINERAL RESEARCH 21,pp.S387-S387
2006/07	Papers	[Effect of vitamin D on the nervous system and the skeletal muscle]. Clinical calcium,pp.1182-1187
2006/03	Papers	Inhibitory effect of long term 1 alpha-hydroxyvitamin D3 administration on Helicobacter pylori infection JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION 38 (2),pp.103-106
2006/03	Papers	Preparation and biological activity of retinoic acid analogs containing an aromatic ring LETTERS IN DRUG DESIGN & DISCOVERY 3 (2),pp.118-122
2006	Papers	Coenzyme Q10 prevents neurodegenerative disease with oxidative stress. ファルマシア
2005/11	Papers	Biological activities of retinoidal gamma-hydroxybutenolides in cancer cell apoptosis and differentiation BIOORGANIC & MEDICINAL CHEMISTRY 13 (21),pp.6002-6008
2005/09	Papers	Vitamin K-dependent gamma-glutamyl carboxylase activity of vitamin K compounds in liver and bone. JOURNAL OF BONE AND MINERAL RESEARCH 20 (9),pp.S137-S137
2005/06	Papers	22-oxa-1 alpha,25-dihydroxyvitamin D-3 inhibits metastasis and angiogenesis in lung cancer CARCINOGENESIS 26 (6),pp.1044-1054
2005/06	Papers	Tissue-type specific anti-cancer effects and vitamin K-dependent gamma-glutamyl carboxylase activity of vitamin K compounds BONE 36,pp.S221-S221
2005/02	Papers	1 alpha,25-Dihydroxyvitamin D-3 is a preventive factor in the metastasis of lung cancer CARCINOGENESIS 26 (2),pp.429-440
2005	Papers	マウスの新生児期・成長期・妊娠期・高齢期におけるビタミンK依存性γ‐Glutamylcarboxylase活性 Osteoporosis Jpn,pp.182-182
2004/07	Papers	Preparation and biological activity of 13-substituted retinoic acids BIOORGANIC & MEDICINAL CHEMISTRY 12 (14),pp.3931-3942
2004/05	Papers	Metastatic growth of lung cancer cells is extremely reduced in vitamin D receptor knockout mice JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 89-90 (1-5),pp.545-547
2003/09	Papers	The development of vitamin D analogs as a therapeutic agent SEIKAGAKU,pp.1233-1238
2003/06	Papers	Metabolism of 26,26,26,27,27,27-F-6-1 alpha,25-dihydroxyvitamin D-3 by CYP24: species-based difference between humans and rats BIOCHEMICAL PHARMACOLOGY 65 (12),pp.1957-1965
2003/06	Papers	Metabolism of 26,26,26,27,27,27-F-6-1 alpha,25-dihydroxyvitamin D-3 by CYP24: species-based difference between humans and rats BIOCHEMICAL PHARMACOLOGY 65 (12),pp.1957-1965
2002/09	Papers	Molecular analysis of the vitamin D receptor interactions with highly potent vitamin D analogues using site-directed mutagenesis. JOURNAL OF BONE AND MINERAL RESEARCH 17,pp.S395-S395
2002/06	Papers	2-Methyl analogues of 1 alpha 25-dihydroxyvitamin D-3, the potent inducers of cell differentiation and apoptosis: synthesis and biological evaluation ANTI-CANCER DRUGS 13 (5),pp.A10-A10
2002/05	Papers	[Novel vitamin d analogues with selective biological activities]. Clinical calcium,pp.645-652
2002	Papers	1 alpha,25-Dihydroxyvitamin D, and menaqunone-4 respectively induce cell differentiation and apoptosis via induction of G0/G1 arrest in human promyelocytic leukemia HL-60 cells INTERNATIONAL JOURNAL OF CANCER,pp.346-346
2002	Papers	Tumor growth and metastasis of lung cancer cells are extremely reduced in vitamin D receptor knockout mice INTERNATIONAL JOURNAL OF CANCER,pp.161-161
2002	Papers	Analysis of Molecular Mechanism of Cancer Cell Differentiation and Apoptosis Induced by Vitamin D3 Analogs on the Basis of Molecular Recognition of Vitamin D Receptor Ligand Binding Domain. 薬学雑誌,pp.781-791
2001/11	Papers	Synthesis and biological evaluation of all A-ring stereoisomers of 5,6-trans-2-methyl-1,25-dihydroxyvitamin D-3 and their 20-epimers: possible binding modes of potent A-ring analogues to vitamin D receptor CHEMISTRY & BIOLOGY 8 (11),pp.1011-1024
2001/09	Papers	Molecular mechanism of differentiation and apoptosis-inducing actions of A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D-3 in human promyelocytic leukemia (HL-60) cells. JOURNAL OF BONE AND MINERAL RESEARCH 16,pp.S555-S555
2001/05	Papers	Molecular mechanism of cell differentiation and apoptosis induced by A-ring analogues of 1alpha,25-dihydroxyvitamin D-3 BONE 28 (5),pp.S98-S98
2001/03	Papers	Differential activities of 1 alpha,25-dihydroxy-16-ene-vitamin D-3 analogs and their 3-epimers on human promyelocytic leukemia (HL-60) cell differentiation and apoptosis STEROIDS 66 (3-5),pp.327-337
2001/03	Papers	Systematic studies on synthesis, structural elucidation, and biological evaluation of A-ring diastereomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and 20-epi-2-methyl-1 alpha,25-dihydroxyvitamin D-3 STEROIDS 66 (3-5),pp.277-285
2001/02	Papers	Highly potent cell differentiation-inducing analogues of 1 alpha,25-dihydroxyvitamin D-3: Synthesis and biological activity of 2-methyl-1,25-dihydroxyvitamin D-3 with side-chain modifications BIOORGANIC & MEDICINAL CHEMISTRY 9 (2),pp.525-535
2001/02	Papers	Synthesis and evaluation of A-ring diastereomers of 1 alpha,25-dihydroxy-22-0xavitamin D-3 (OCT) BIOORGANIC & MEDICINAL CHEMISTRY 9 (2),pp.403-415
2001	Books	Biological activity of vitamin D analogs
2001	Papers	Asymmetric catalytic ene-cyclization approach to 2-fluoro- 19-nor-1,25-dihydroxyvitamin D3 A-ring analog with significant transactivation activity Chirality 13 (7),pp.366-371
2000/12	Papers	Structure-specific control of differentiation and apoptosis of human promyelocytic leukemia (HL-60) cells by a ring diastereomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and its 20-epimer BIOCHEMICAL PHARMACOLOGY 60 (12),pp.1937-1947
2000/09	Papers	Structure-specific and concentration-dependent stimulation of apoptosis by A-ring stereoisomers of 1 alpha,25-dihydroxyvitamin D-3 in HL-60 cells. JOURNAL OF BONE AND MINERAL RESEARCH 15,pp.S575-S575
2000/05	Papers	Biological activities of 19-nor-1 alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring CURRENT PHARMACEUTICAL DESIGN 6 (7),pp.791-801
2000/05	Papers	Biological activities of 19-nor-1 alpha,25-dihydroxyvitamin D3 analogs singly dehydroxylated at the C-1 or C-3 position of the A-ring CURRENT PHARMACEUTICAL DESIGN 6 (7),pp.791-801
2000/05	Papers	Syntheses and biological evaluation of novel 2 alpha-substituted 1 alpha,25-dihydroxyvitamin D-3 analogues BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 10 (10),pp.1129-1132
2000/03	Papers	Catalytic asymmetric syntheses and biological activities of singly dehydroxylated 19-nor-1 alpha,25-dihydroxyvitamin D-3 A-ring analogs in cancer cell differentiation and apoptosis CHEMISTRY & BIOLOGY 7 (3),pp.173-184
2000/03	Papers	Catalytic asymmetric syntheses and biological activities of singly dehydroxylated 19-nor-1 alpha,25-dihydroxyvitamin D-3 A-ring analogs in cancer cell differentiation and apoptosis CHEMISTRY & BIOLOGY 7 (3),pp.173-184
2000/03	Papers	Novel ring A stereoisomers of 2-methyl-1 alpha,25-dihydroxyvitamin D-3 and 2-methyl-20-epi-1 alpha,25-dihydroxyvitamin D-3: Transactivation of target genes and modulation of differentiation in human promyelocytic leukemia (HL-60) cells BIOCHEMICAL PHARMACOLOGY 59 (6),pp.691-702
2000/02	Papers	Absorption of calcium, magnesium, phosphorus, iron, and zinc in growing male rats fed diets containing either phytate-free soybean protein or soybean protein isolate or casein JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 46 (1),pp.34-41
2000/02	Papers	Absorption of calcium, magnesium, phosphorus, iron, and zinc in growing male rats fed diets containing either phytate-free soybean protein or soybean protein isolate or casein JOURNAL OF NUTRITIONAL SCIENCE AND VITAMINOLOGY 46 (1),pp.34-41
2000/01/01	Papers	Efficient synthesis and biological evaluation of all A-ring diastereomers of 1α,25-dihydroxyvitamin D3 and its 20-epimer Bioorganic and Medicinal Chemistry 8 (1),pp.123-134
2000/01	Papers	Efficient synthesis and biological evaluation of all A-ring diastereomers of 1 alpha,25-dihydroxyvitamin D-3 and its 20-epimer BIOORGANIC & MEDICINAL CHEMISTRY 8 (1),pp.123-134
2000/01	Papers	In vitro biological activities of a series of 2 beta-substituted analogues of 1 alpha,25-dihydroxyvitamin D-3 BIOLOGICAL & PHARMACEUTICAL BULLETIN 23 (1),pp.66-71
2000/01	Papers	In vitro biological activities of a series of 2 beta-substituted analogues of 1 alpha,25-dihydroxyvitamin D-3 BIOLOGICAL & PHARMACEUTICAL BULLETIN 23 (1),pp.66-71
2000	Papers	Synthesis of 2-Fluoro-19-nor Vitamin D Analogues Based on Asymmetric Catalytic Carbonyl-Ene Cyclization. 日本化学会講演予稿集
1999/12	Papers	BINOL-Ti-catalyzed carbonyl-ene cyclization by tuning the 6-Br-ligand for the synthesis of 2-methyl-19-nor-22-oxa vitamin D analogue with significant differentiation activity SYNLETT 12 (12),pp.1899-1902
1999/10	Papers	Rapid control of transmembrane calcium influx by 1 alpha,25-dihydroxyvitamin D-3 and its analogues in rat osteoblast-like cells BIOLOGICAL & PHARMACEUTICAL BULLETIN 22 (10),pp.1058-1063
1999/09	Papers	Structure-specific control of apoptosis by novel 2-methyl-A-ring stereoisomers of l alpha,25-dihydroxyvitamin D-3, and 20-epi-1 alpha,25-dihydroxyvitamin D-3 in HL-60 cells. JOURNAL OF BONE AND MINERAL RESEARCH 14,pp.S214-S214
1999/04	Papers	Biological activity profiles of 1 alpha,25-dihydroxyvitamin D-2, D-3, D-4, D-7 and 24-epi-1 alpha,25-dihydroxyvitamin D-2 BIOLOGICAL & PHARMACEUTICAL BULLETIN 22 (4),pp.371-377
1999	Papers	Biological Activities of 19-Nor-1α,25-dihydroxyvitamin D₃ Analogues with Singly Dehydroxylated at the Position 1 or 3 of the A-Ring. ビタミン,pp.635-647
1999	Papers	Biological Activities of 19-Nor-1α, 25-dihydroxyvitamin D₃ Analogues with Singly Dehydroxylated at the Position Lor 3 of the A-Ring.,pp.635-647
1999	Papers	Intestinal absorption of calcium from calcium ascorbate in rats JOURNAL OF BONE AND MINERAL METABOLISM 17 (1),pp.30-36
1999	Papers	Apoptosis and calcium. Apoptosis and calcium absorption in intestine. Clinical Calcium,pp.40-45
1999	Papers	Synthesis of 2-Methyl-19-norvitamin D Analogues Based on Asymmetric Catalytic Carbonyl-Ene Cyclizations. 日本化学会講演予稿集
1998/12	Papers	Singly dehydroxylated a-ring analogues of 19-nor-1 alpha-25-dihydroxyvitamin D-3 and 19-nor-22-oxa-1 alpha,25-dihydroxyvitamin D-3: Novel vitamin D-3 analogues with potent transcriptional activity but extremely low affinity for vitamin D receptor BIOLOGICAL & PHARMACEUTICAL BULLETIN 21 (12),pp.1300-1305
1998/05	Papers	"Symmetry" in the synthesis of the A-ring of a vitamin D hybrid analogue with significant transactivation activity: A combinatorial sequence of regioselective propiolate-ene, catalytic enantioselective epoxidation and carbonyl-ene cyclization reactions TETRAHEDRON LETTERS 39 (21),pp.3359-3362
1998	Papers	Biological activities of D3 derivative of 19-nor-vitamin with hydroxyl group in 1 or 3 position of A ring. 日本薬学会年会要旨集
1998	Papers	Vitamin D Analogues CLINICAL CALCIUM,pp.9-17
1998	Papers	From fundamentals of vitamin D to clinics. Vitamin D derivatives. Clinical Calcium,pp.9-17
1998	Papers	Intestinum tenue calcium absorbability of the calcium ascorbate in the rat. 日本薬学会年会要旨集
1998	Papers	Synthesis of Hybrid Type Vitamin D Analogues Based on the Asymmetric Catalytic Carbonyl-Ene Cyclization. 日本化学会講演予稿集
1998	Papers	Effects of di-phytic acid soybean protein on mineral absorption and bone metabolism. 日本栄養・食糧学会総会講演要旨集
1997	Papers	In vitro bone resorption and differentiation induction activity of 1.ALPHA.,25-dihydroxyvitamin D4. 日本骨代謝学会雑誌
1997	Papers	Biological Activity of 1α, 25-Dihydroxyviamin D₄ : a Comparative in vitro Study with 1α, 25 Dihydroxyvirtamin D₂ and 1α, 25-Dilydroxyvitamin D₃" Vitamin D, Chemisty, Biology and Clinical Applications of the Steroid Hormone(Proceeding of the Tenth Workshop on Vitamin D),pp.7
1997	Papers	Relevance between pharmacodynamic property, and intestinum tenue calcium transport property and Calbindin-D9k induction potency of vitamin D derivative. 日本薬学会年会要旨集
1997	Papers	Intracellular calcium concentration rising action of active vitamin D derivatives in rat bone osteoblastic sarcoma cells (ROS17/2,8). 日本骨代謝学会雑誌
1997	Papers	Increasing action of intracellular calcium concentration of 1.ALPHA.,25-Dihydroxy-vitamin D3 in rat octecoblast sarcoma cell (ROS17/2.8) 日本薬学会年会要旨集